Tet-Off RMA

A kinetic model for inducible RMA expression under the tetracycline responsive element..

Usage

rma_kinetics.models.tetoff.Model

Tet-Off RMA expression model.

__init__(rma_prod: float = 0.2, leaky_rma_prod: float = 0.002, rma_bbb_transport: float = 0.6, rma_deg: float = 0.007, tta_prod: float = 10.0, tta_deg: float = 1.0, tta_kd: float = 10.0, tta_cooperativity: float = 2.0, dox_pk_model: dox.Model = ..., dox_tta_kd: float = 10.0) -> None

solve(t0: float, tf: float, dt: float, init_state: State, solver: Solver) -> Solution

rma_kinetics.models.tetoff.State

Tet-Off model state.

brain_rma: float property writable

plasma_rma: float property writable

tta: float property writable

brain_dox: float property writable

plasma_dox: float property writable

__init__(brain_rma: float = 0.0, plasma_rma: float = 0.0, tta: float = 0.0, brain_dox: float = 0.0, plasma_dox: float = 0.0) -> None