Dox

Doxycycline pharmacokinetic model describing dox dynamics in plasma and brain.

Usage

rma_kinetics.models.dox.Model

Dox PK model

__init__(vehicle_intake: float = 0.0001875, bioavailability: float = 0.9, absorption: float = 0.8, elimination: float = 0.2, brain_transport: float = 0.2, plasma_transport: float = 1.0, plasma_vd: float = 0.21, schedule: List[AccessPeriod] = ...) -> None

solve(t0: float, tf: float, dt: float, init_state: State, solver: Solver) -> Solution

rma_kinetics.models.dox.State

Dox PK model state.

plasma_dox: float property writable

brain_dox: float property writable

__init__(plasma_dox: float = 0.0, brain_dox: float = 0.0) -> None

rma_kinetics.models.dox.AccessPeriod

Defines the concentration and period of access of dox food or water.

dose: float property

start_time: float property

stop_time: float property

__init__(dose: float, start_time: float, stop_time: float) -> None

rma_kinetics.models.dox.create_dox_schedule(dose: float, start_time: float, duration: float, repeat: Optional[int] = None, interval: Optional[float] = None) -> List[AccessPeriod]