Chemogenetic RMA

Kinetic model describing the genetic cicruit for monitoring neuronal activity with serum markers (Lee et al., 2024, Buitrago et al., 2025).

Usage

rma_kinetics.models.chemogenetic.Model

Chemogenetic RMA expression model.

__init__(rma_prod: float = 0.2, leaky_rma_prod: float = 0.002, rma_bbb_transport: float = 0.6, rma_deg: float = 0.007, tta_prod: float = 10.0, leaky_tta_prod: float = 0.002, tta_deg: float = 1.0, tta_kd: float = 10.0, tta_cooperativity: float = 2.0, dox_pk_model: DoxModel = ..., dox_tta_kd: float = 10.0, cno_pk_model: CNOModel = ..., cno_ec50: float = 1000.0, clz_ec50: float = 1000.0, cno_cooperativity: float = 2.0, clz_cooperativity: float = 2.0, dreadd_prod: float = 0.2, dreadd_deg: float = 0.007, dreadd_ec50: float = 1000.0, dreadd_cooperativity: float = 2.0) -> None

solve(t0: float, tf: float, dt: float, init_state: State, solver: Solver) -> Solution

rma_kinetics.models.chemogenetic.State

Chemogenetic RMA expression model state.

brain_rma: float property writable

plasma_rma: float property writable

tta: float property writable

plasma_dox: float property writable

brain_dox: float property writable

dreadd: float property writable

peritoneal_cno: float property writable

plasma_cno: float property writable

brain_cno: float property writable

plasma_clz: float property writable

brain_clz: float property writable

__init__(brain_rma: float = 0.0, plasma_rma: float = 0.0, tta: float = 0.0, plasma_dox: float = 0.0, brain_dox: float = 0.0, dreadd: float = 0.0, peritoneal_cno: float = 0.0, plasma_cno: float = 0.0, brain_cno: float = 0.0, plasma_clz: float = 0.0, brain_clz: float = 0.0) -> None