CNO

A CNO/CLZ pharmacokinetic model describing CNO and CLZ dynamics in plasma and brain.

Usage

rma_kinetics.models.cno.Model

CNO PK model.

__init__(doses: List[Dose] = ..., cno_absorption: float = 23.94, cno_elimination: float = 0.0, cno_reverse_metabolism: float = 0.0, clz_metabolism: float = 0.0, clz_elimination: float = 0.0, cno_brain_transport: float = 0.0, cno_plasma_transport: float = 0.0, clz_brain_transport: float = 0.0, clz_plasma_transport: float = 0.0, cno_plasma_vd: float = 0.0, cno_brain_vd: float = 0.0, clz_plasma_vd: float = 0.0, clz_brain_vd: float = 0.0) -> None

solve(t0: float, tf: float, dt: float, init_state: State, solver: Solver) -> Solution

rma_kinetics.models.cno.State

CNO model state.

peritoneal_cno: float property writable

plasma_cno: float property writable

brain_cno: float property writable

plasma_clz: float property writable

brain_clz: float property writable

__init__(peritoneal_cno: float = 0.0, plasma_cno: float = 0.0, brain_cno: float = 0.0, plasma_clz: float = 0.0, brain_clz: float = 0.0) -> None

rma_kinetics.models.cno.Dose

Defines a CNO dose given an amount in mg and administration time.

mg: float property writable

nmol: float property writable

time: float property writable

__init__(mg: float, time: float) -> None

rma_kinetics.models.cno.create_cno_schedule(mg: float, start_time: float, repeat: Optional[int] = None, interval: Optional[float] = None) -> List[Dose]